19
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13244 | Ubiquitination-IN-1 | Others | |
Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM). | |||
T37042 | SCH529074 | SCH 529074 | p53 |
SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. | |||
T16904 | Smurf1-IN-A01 | A01 | Others |
Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. | |||
T8773 | MID-1 | Others , IGF-1R | |
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet... | |||
T79133 | UC-764864 | E1/E2/E3 Enzyme | |
UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in leukemic cells. It effectively hinders the ubiquitination of sub... | |||
T69977 | BC-1485 | ||
BC-1485 is a first-in-class inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1 ), which disrupts FIEL1-directed PIAS4 ubiquitination. | |||
T80686 | γ-AA peptide P6 | ||
γ-AA peptide P6 acts as a potent activator of E6 associated protein (E6AP), facilitating both its self-ubiquitination and the ubiquitination of E6AP substrates in vitro reconstituted reactions. Furthermore, γ-AA peptide ... | |||
T17868 | E3 ligase Ligand 10 | Others | |
E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated d... | |||
T75030 | Ubiquitination-IN-2 | ||
Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein−protein interactions (PPI), displaying inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the trans... | |||
T37646 | HB007 | ||
HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for in... | |||
T61776 | TEAD-IN-2 | ||
TEAD-IN-2 is an innovative, orally bioavailable inhibitor that targets the transcriptional enhancer associate domain (TEAD). It functions by regulating TEAD through ubiquitination and/or degradation by specific compounds... | |||
T17363 | β-Naphthoflavone-CH2-OH | β-NF-CH2-OH | Others |
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These... | |||
T61688 | Nrf2 activator-2 | ||
Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 acti... | |||
T37329 | PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 | |
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the... | |||
T78221 | TRAF6 peptide TFA | E1/E2/E3 Enzyme | |
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde... | |||
T36800 | EN219 | ||
EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and ... | |||
T82610 | DA-PROTAC | PROTACs | |
DA-PROTAC is a potent degrader of the copper ion-transport proteins Atox1 and CCS, capable of binding to both proteins and facilitating their association with E3 ligase. This interaction enhances the ubiquitination and s... | |||
T79718 | CaMKIIα-PHOTAC | CaMK | |
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule facilitates the ubiquitination and subsequent proteasome-medi... | |||
T83667 | A11 TFA | CPP-EYVQTVKSSKG | |
A11, a cell-penetrating peptide, integrates the HIV-1 Tat protein transduction domain with an 11-amino acid segment from the annexin A1 N-terminus (residues 20-30). This compound disrupts the interaction between annexin ... |